It is always exciting to learn about innovative technologies that have the potential to transform the way we approach disease treatment. Transine Therapeutics is one such company that is leading the way in the field of targeted translation enhancers, also known as SINEUPs, a platform for physiological upregulation of proteins. In this startup showcase, we delve into the world of Transine Therapeutics and explore how their pioneering technology is expected to revolutionize the treatment of hard-to-treat diseases.
Introduction
Transine Therapeutics is a UK-based private biotechnology company founded in 2016 by Marco Marcia, Eric Swayze, and David Corey, three scientists with extensive experience in the field of RNA biology and drug development. The goal of the company is to harness the power of SINEUPs – a novel class of RNAs discovered by the co-founders – to upregulate protein expression in a targeted and controllable manner. SINEUPs work by binding to the mRNA of a specific protein of interest and enhancing its translation, resulting in an increase in the level of the protein produced.
Revolutionizing Protein Expression
The ability to upregulate protein expression with such precision has enormous therapeutic potential. By using SINEUPs, Transine Therapeutics aims to expand the druggable proteome, enabling the treatment of diseases that have been historically difficult to target using conventional drug modalities. The company’s current focus is on central nervous system disorders and ophthalmologic disorders, but the platform has the potential to be applied to many disease areas.
Transine Therapeutics has already demonstrated the efficacy of their SINEUPs technology in pre-clinical models of Huntington’s disease, a devastating neurodegenerative disorder for which there is currently no cure. SINEUPs designed to upregulate the expression of the Huntingtin protein showed a significant reduction in neuronal dysfunction and cell death in a mouse model of the disease. These promising results have led to the development of a lead drug candidate for Huntington’s disease that is currently undergoing preclinical testing.
Impactful Partnerships
Transine Therapeutics has also made significant strides in establishing partnerships with leading pharmaceutical companies to develop SINEUPs for a wide range of diseases. In 2019, the company announced a partnership with Biogen, a global leader in neuroscience drug development, to develop SINEUPs for the treatment of neurological diseases. This high-profile partnership further validates the potential of SINEUPs as a novel therapeutic modality and provides Transine Therapeutics with the resources and expertise needed to advance their technology towards clinical trials.
Looking to the Future
The potential of SINEUPs extends beyond just upregulating protein expression. The technology could also be used to improve the efficacy and safety of gene therapies, enabling a more precise control of gene expression. Transine Therapeutics is also exploring the use of SINEUPs in the field of gene editing, where it could be used to upregulate the expression of genes involved in repairing DNA damage.
Conclusion
Transine Therapeutics is an exciting biotech company that is changing the field of therapeutic RNA development with its innovative SINEUPs technology. The company’s platform has already demonstrated significant potential in preclinical models of disease and has established partnerships with top pharmaceutical companies to bring its technology closer to the clinic. With a broad range of applications and a commitment to improving the lives of patients with hard-to-treat diseases, Transine Therapeutics is a company to watch in the biotech industry.
Website: https://www.transinetx.com/
Twitter: https://twitter.com/transinetx
LinkedIn: https://www.linkedin.com/company/transine-therapeutics/
Want to supercharge your brand’s visibility within the UK tech industry? Reach startup founders, investors, and C-level executives with sponsored articles on UKT.news. Connect with us and discover how our advertising solutions can propel your brand to new heights. Explore our Sponsored Articles & Partnerships Program here.
